LEASE

THIS LEASE ("Lease") entered into as of the 22nd day of May, 2000, between BRANDYWINE OPERATING PARTNERSHIP, L. P., a Delaware limited partnership having its principal office at 14 Campus Boulevard, Suite 100, Newtown Square, Pennsylvania 19073 ("Landlord"), and THE IMMUNE RESPONSE CORPORATION, a Delaware corporation with its principal place of business at 5935 Darwin Court, Carlsbad, California ("Tenant").

WITNESSETH

In consideration of the mutual covenants herein set forth, and intending to be legally bound, the parties hereto covenant and agree as follows:

1. SUMMARY OF DEFINED TERMS.

The parties agree that the following defined terms, as used in this Lease, shall have the meanings and shall be construed as set forth below:

(a) "BUILDING": The Building owned by Landlord in fee and located at 660 Allen dale Road, King of Prussia, Pennsylvania, and identified as Unit 660 in the condominium complex known as Brandy wine King of Prussia.

(b) "PROJECT": The Building, the land, the portions of the Parking Area (as hereinafter defined) which are for the exclusive use of Tenant and allot her improvements located at 660 Allen dale Road, King of Prussia, Pennsylvania.

(c) "PREMISES": Unit No. 660, which the parties hereto hereby stipulate and agree is the entire 50,635 square feet of the Building shown on the Site Plan attached hereto as Exhibit "A" and made a part hereof.

(d) "term ": From June 1, 2000 to October 31, 2011.

(e) "FIXED RENT": Tenant shall pay to Landlord fixed rent as set forth in the Rental Schedule contained in Section 5 of the Lease.

(f) "SECURITY DEPOSIT": $30,000.00;

(g) "EFFECTIVE DATE": June 1, 2000;

(h) "TENANT'S ALLOCATED SHARE COMMON AREAS": 47.77%

(i) "RENTABLE AREA": Premises 50,635 Building 50,635

(j) "PERMITTED USES": Tenant's use of the Premises shall be limited to general bio-pharmaceutical research and development, product production and distribution, including, general office and industrial uses and storage incidental thereto, in accordance with all applicable laws and in keeping with existing governmental zoning and permitted uses.

(k) "BROKER": CB Richard Ellis;